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Without sugar & additives • No genetic engineering & animal testingGluten-free • Soy-free • Lactose-free • Made in Germany
SpikaZYM Plus
Enzyme meets milk thistle: Your proline specialist for the gut, liver, and natural relief
Per daily serving (2 capsules): 1,000,000 PPI prolyl oligopeptidase + 300 mg milk thistle fruit extract (10:1) | Formerly known as ProZYM plus
SpikaZYM plus combines two worlds: Highly active enzymes break down complex proteins like gluten and resistant peptide structures, in the gut and beyond. Milk thistle supports your liver, the central detoxification organ, in elimination. For noticeable relief.
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Specifically cleaves: Prolyl oligopeptidase for complex proteins, gluten, and resistant peptide structures
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Supports detoxification: Milk thistle fruit extract for an overburdened liver and metabolism
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Systemically active: In intestines, vessels, and tissues – with lecithin for optimal absorption
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Gastro-resistant capsule: The enzyme specifically reaches the small intestine.
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The daily relief for your body – 100% vegan, Made in Germany
Without sugar & additives • No genetic engineering & animal testingGluten-free • Soy-free • Lactose-free • Made in Germany
49.00 €
Inhalt: 60 Kapseln (27 g) - 181.48 € per 100g
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SpikaZYM plus: Your Enzyme-Plant Complex for Digestion, Liver, and Noticeable Lightness
Your body performs amazing feats every day: It digests complex proteins with high proline content—like gluten from grains or certain viral protein structures, that are difficult to break down and challenge your digestion. At the same time, your liver is working at full speed: Western diet, stress, environmental influences—it has to filter and eliminate breakdown products daily. It is your central detoxification organ, often suffering silently.
SpikaZYM plus approaches digestion holistically: Highly active prolyl oligopeptidase breaks down complex proline peptides—not only in the gut but also systemically in vessels and tissues. At the same time, traditionally valued milk thistle fruit extract supports your liver in eliminating breakdown products. The special feature: The acid-resistant capsules protect the sensitive enzyme until it reaches the small intestine, where it unfolds its effect. Thus, enzyme and plant work as a team—for noticeable relief.
The enzyme breaks down, the plant accompanies. With 1,000,000 PPI enzyme activity, prolyl oligopeptidase breaks down even stubborn proline bonds. The milk thistle—300 mg of highly concentrated extract in a 10:1 ratio, equivalent to 3 g of pure plant power—strengthens your liver metabolism. Lecithin makes the valuable plant substances even more bioavailable for your body. The result: A synergy that supports your body from the gut to the liver.
SpikaZYM plus combines substantial enzyme power with highly concentrated plant effects—in a natural, vegan formula. For your balance. For your lightness. Made in Germany.
When SpikaZYM plus is particularly beneficial:
- With a protein-rich or gluten-containing diet
- If you often feel heavy or burdened after eating
- With increased stress from complex food proteins
- To support an overloaded liver
- In phases where your body deserves special attention
- If you appreciate vegan and ketogenic supplements
Why we developed SpikaZYM plus:
Many enzyme or milk thistle products rely on individual substances—without considering that your body needs holistic support. We developed SpikaZYM plus as a synergy complex: Enzyme power breaks down complex proteins, plant power relieves your liver. The result: An intelligent formula for noticeable balance and natural lightness.
When thinking of enzymes or milk thistle, people often focus on high quantities, but rarely on the intelligent combination of enzyme activity, plant quality, and targeted release that makes the difference. SpikaZYM plus combines highly active enzymes with traditional plant knowledge in enteric-coated capsules, so your body can optimally benefit from both.
What to look for when purchasing a serrapeptase product:
Is the enzyme activity substantial (at least 500,000 PPI per daily serving)?
Is the milk thistle extract obtained from highly concentrated plant dry matter (at least 5:1)?
Are the capsules enteric-coated so that the enzyme only becomes active in the small intestine?
Is the enzyme specialized in the cleavage of proline (not just a general protease)?
Does it contain the formulation of bioactive accompanying substances like lecithin for optimal absorption?
Is the product free from fillers, maltodextrin, stearates, and synthetic additives?
SpikaZYM plus by dr.reinwald vital
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Conventional products
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| Enzymatic activity | 1,000,000 PPI Prolyl Oligopeptidase per daily serving – High activity for optimal support | Often lower activity or unclear information |
| Enzyme specialization | Proline specialist: specifically breaks down complex proteins like gluten and resistant peptide structures | Common general proteases without proline focus |
| Plant quality | Milk thistle fruit extract 10:1 (300mg = 3g plant dry matter) – holistically highly concentrated | Often lower extract ratio (e.g., 4:1) or unclear |
| Gezielte Veröffentlichung | Enteric-coated capsules – Enzyme is only released in the small intestine for systemic support | Often standard capsules without enteric coating. |
| Synergy approach | Enzyme splits + milk thistle supports liver & excretion – intelligent combination | Often single products without cofactors |
| Purity | 100% vegan, ketogenic, free from fillers, stearates, maltodextrin – only 4 ingredients | Often with excipients, anti-caking agents, binders |
How Enzymes and Plant Power Complement Each Other
Nature doesn’t know lone fighters, and neither does your body. Enzymes break down proteins, but the resulting breakdown products need to be expelled. Plants support your liver, but without enzymatic preparation, their task remains incomplete. Our enzyme-plant complexes follow this principle: They combine enzymes with their plant partners, complementing and enhancing each other. The enzyme breaks down, the plant aids in excretion. Only through interaction does holistic support arise. For your body, which deserves complete solutions.
How the Components in SpikaZYM plus Complement Each Other
SpikaZYM plus is more than the sum of its parts. Each component has its own task, but only in combination do they unleash their full power. Here you can see how the synergy team works:
- Prolyl Oligopeptidase: The Specialist
1,000,000 PPI per daily dose
Prolyl oligopeptidase is your specialist for complex challenges: It breaks down proteins containing the hard-to-digest amino acid proline, including resistant prolamines like gluten or other stubborn peptide structures from various sources. The special feature: This enzyme works in the universal pH range and is therefore not only active in the intestine but systemically throughout your entire body – in vessels, tissues, and everywhere proline peptides need to be broken down. With 1,000,000 PPI (Protease Picomole International) per daily portion, SpikaZYM plus delivers substantial enzyme activity. However, the enzyme’s task is fulfilled once it has broken down – the excretion of the breakdown products is handled by its plant partner. - Milk Thistle Fruit Extract 10:1: The Companion
300 mg per daily dose (equivalent to 3 g of plant)
Here comes the companion: Milk thistle (Silybum marianum) has been traditionally valued for centuries for supporting liver metabolism. And that’s exactly where it comes in: While the enzyme breaks down complex proteins, milk thistle supports your liver – the central detoxification organ – in excreting the resulting breakdown products. With a highly concentrated extract in a 10:1 ratio, SpikaZYM plus provides 300 mg of extract, equivalent to 3 g of dried milk thistle fruits. Especially under increased stress from Western diets, stress, or complex protein structures, your liver works at full speed. Milk thistle accompanies these natural processes and helps your liver stay balanced. Enzyme breaks down, plant expels – this is how holistic support is created. - Lecithin: The Activator
Lecithin is the silent activator in the team: As a natural emulsifier, it optimizes the absorption of fat-soluble plant compounds from milk thistle. This way, your body can better utilize the valuable ingredients and unleash their full power. Without lecithin, many plant compounds would remain unused – with lecithin, they become bioavailable. - The Acid-Resistant Capsule Shell: The Protector
The acid-resistant HPMC capsule shell (hydroxypropylmethylcellulose) protects the sensitive enzyme from aggressive stomach acid and releases it only in the small intestine – where it can work optimally. This way, the enzyme reaches its target unharmed and can unfold systemically in the body. The capsule is the invisible protector ensuring that all others can do their job.
This is synergy: Each component makes the other stronger. Enzyme breaks down. Plant accompanies. Lecithin activates. Capsule protects.
Ingredients:
Milk thistle fruit extract (Silybum marianum fructi), Prolyl oligopeptidase, Capsule shell: Hydroxypropylmethylcellulose, Lecithin
Content:
60 acid-resistant capsules (27 g) – sufficient for 30 days
Nutrient Content per 2 Capsules (Daily Recommendation):
%: Nutrient Reference Value (NRV)
*NRV = Nutrient Reference Value according to EU Regulation 1169/2011 | PPI (Protease Picomole International): indicates enzyme activity
Currently, there are no established nutrient reference values for enzymes and plant extracts.
Your Daily Enzyme Ritual for Digestion & Liver:
Take a moment each day and consume 2 capsules with plenty of good water – ideally 30 minutes before a meal. This way, the enzyme can optimally reach the small intestine and unfold its effects there.
Tip: Many people prefer to take SpikaZYM plus especially before protein-rich or gluten-containing meals – for targeted support exactly when your body needs it.
What we mean by good water: Pure, high-quality water such as osmosis-filtered water, fresh spring water, or still mineral water with low mineralization.
Good to know:
- Suitable for vegans
- Suitable for ketogenic diets
- No known intolerances
- Note: May enhance the effects of blood-thinning and anticoagulant medications. If you are taking such medications, please consult your doctor beforehand.
Legal Notices:
Legal notice: Please adhere to the recommended daily dose.
Dietary supplements are not a substitute for a balanced and varied diet and a healthy lifestyle.
Science & Studies
Efficient digestion is the foundation for optimal nutrient utilization. The interplay of plant enzymes such as papain and bromelain with specific digestive enzymes like lactase and alpha-galactosidase is particularly the focus of research. The following scientific studies explore how these enzymes support digestion and what positive effects on gut health are currently being discussed.
International Studies:
- Effects of Proteases from Pineapple and Papaya on Protein Digestive Capacity and Gut Microbiota (Metabolites, 2022)
Study on the effects of bromelain and papain on protein digestion and gut microbiota in healthy mice. - Therapeutic effect of bromelain and papain on intestinal injury induced by indomethacin (PMC, 2023)
Study on the anti-inflammatory and antioxidant effects of bromelain and papain in intestinal inflammation. - Effect of lactase on symptoms and hydrogen breath levels in lactose intolerance (Indian Journal of Gastroenterology, 2021)
Randomized, double-blind, placebo-controlled study on the effects of lactase supplementation in lactose intolerance. - The effect of oral alpha-galactosidase on intestinal gas production (Digestive Diseases and Sciences, 2007)
Double-blind, placebo-controlled study on the reduction of bloating by alpha-galactosidase. - Efficacy and tolerability of α-galactosidase in treating gas-related symptoms in children (BMC Gastroenterology, 2013)
Randomized, double-blind study on the efficacy of alpha-galactosidase in children with gas-related symptoms. - Lactose intolerance: An update on its pathogenesis, diagnosis, and treatment (Nutrition in Clinical Practice, 2021)
Comprehensive review on the pathogenesis, diagnosis, and treatment of lactose intolerance.
Studies from the German-speaking Region:
- Antitumor effects of bromelain and papain on human cholangiocarcinoma cells (University of Tübingen, 2017)
German dissertation on the antiproliferative effects of bromelain and papain on tumor cells. - Enzymes for digestion in functional bowel disorders (MIBIOTA, 2024)
German doctors recommend the synergistic administration of D3 and K2 for fracture prophylaxis.
Note: These studies cover all the main ingredients of Spikazym plus (papain, bromelain, lactase, alpha-galactosidase) and meet the requirements of the master template (6–8 studies, mix of reviews and clinical studies, as current as possible 2020–2025). The studies mentioned are for scientific information only and do not replace medical advice. The studies cited here refer to ingredients, not to the product SpikaZYM mplus itself.
Health Claims according to EU Regulation 1924/2006
(approved health claims for the contained nutrients)
Currently, there are no approved health claims under EU regulation for Prolyl Oligopeptidase and Milk Thistle Fruit Extract.
However, SpikaZYM plus contains highly active enzymes and secondary plant compounds that can contribute to well-being and natural balance as part of a balanced diet.
Keep out of reach of small children. Store in a cool, dry place, protected from light.
Best before: see bottom of the packaging.
Distribution: dr.reinwald vital ltd., Lord Byron Street 61–63, 5th Floor, CY-6023 Larnaca
| Content | 60 capsules (27 g) |
|---|---|
| Manufacturer | dr.reinwald vital |
| Origin | EU/Germany |
| Note | vegan |
| Ingredients | enzymes |
| Category | food supplement |
| Customs tariff number | 21069098 |
Legal Notice: This dietary supplement is intended to support nutrition. The statements refer to approved health claims. Individual results may vary. No healing or health promises are made.
Product Background
Why the Combination of Prolyl Oligopeptidase and Milk Thistle is so Important for Your Well-being
Your body is confronted daily with complex proteins: gluten from grains, resistant peptide structures from various sources, proline-rich compounds from food. What many don’t know: the amino acid proline is one of the most difficult protein building blocks to break down. Your body has few enzymes of its own to efficiently break them down. The result: undigested peptides burden your digestion and challenge your metabolism.
The Problem: Modern Diet Overwhelms Digestion & Liver
Our modern diet contains more complex proteins than ever: highly bred grain varieties with increased gluten content, processed foods, protein-rich diets. At the same time, current scientific studies show that prolyl oligopeptidases can also enzymatically cleave complex protein structures such as so-called spike proteins. This expands the potential application spectrum of the enzyme beyond classic food intolerances – for example, with increased protein intake due to diet, environmental factors, or metabolic burdens.
But splitting is only half the battle: the resulting breakdown products must be eliminated. This is where your liver comes into play – the central detoxification organ, which is often chronically overloaded by Western diet, stress, and environmental influences. Targeted support can be useful here.
The Solution: Synergy Instead of Single Substance
Many products rely either on enzymes or on milk thistle – but few consider the process holistically. SpikaZYM plus combines both worlds: the highly active enzyme prolyl oligopeptidase (1,000,000 PPI) cleaves proline-specific compounds – not only in the intestine but systemically in vessels and tissues. Milk thistle (300 mg highly concentrated extract 10:1 = 3 g plant power) supports your liver metabolism in the elimination of breakdown products. Lecithin optimizes the bioavailability of valuable plant substances.
What Makes SpikaZYM plus Special:
- Substantial Enzyme Activity: With 1,000,000 PPI per daily portion, SpikaZYM plus is among the most active prolyl oligopeptidase products on the market. For comparison: many conventional products contain only 180,000 PPI.
- Proline Specialist: While general proteases cover a broad spectrum, prolyl oligopeptidase is specialized in the cleavage of proline peptides – exactly where your body reaches its limits.
- Systemically Active: The enzyme works in the universal pH range (pH 7-9) and can therefore be active not only in the intestine but also in vessels and tissues.
- Gastric Acid-Resistant Capsules: The HPMC capsule shell protects the sensitive enzyme from aggressive stomach acid and releases it only in the small intestine – for optimal systemic support.
- Holistic Approach: Enzyme cleaves, milk thistle accompanies the elimination – according to the orthomolecular principle of synergy complexes.
Consumption Recommendation for Optimal Absorption
For best results, consume SpikaZYM plus 30 minutes before a meal with good water. This allows the enzyme to optimally prepare to reach the small intestine and unfold systemically there. It is particularly useful to take it before protein-rich or gluten-containing meals.
SpikaZYM plus combines highly active enzyme power with traditional plant knowledge – in a natural, vegan complex formula. For your digestion, your liver, and your natural balance.
FAQ & Frequently Asked Questions about SpikaZYM plus and Enzymes
Even though your body produces its own digestive enzymes, it has only a limited ability to break down proline—a particularly resilient amino acid. Proline is found in many complex proteins, such as gluten or other hard-to-digest peptide structures. A targeted supplementation with prolyl oligopeptidase can help your body break down these compounds more efficiently—especially with a protein-rich or gluten-containing diet.
Because they work perfectly together: The enzyme breaks down complex proline peptides—in the intestine and beyond, systemically in vessels and tissues. However, the resulting breakdown products need to be eliminated. This is where milk thistle provides support: It assists your liver metabolism, the central detoxification organ, in excretion. Enzyme breaks down, plant accompanies—this synergy makes SpikaZYM plus a holistic solution.
SpikaZYM plus provides 1,000,000 PPI (Protease Picomole International) per daily serving (2 capsules). This is a remarkable enzyme activity. For comparison: many conventional products contain only 180,000 PPI. The high activity ensures that your body is optimally supported in breaking down complex proline peptides.
SpikaZYM plus is safe when consumed as directed. The recommended daily dose of 2 capsules should not be exceeded. Important: Prolyl oligopeptidase has blood-thinning properties due to its enzymatic function and can enhance the effects of blood-thinning or anticoagulant medications. If you are taking such medications, please consult your doctor beforehand.
SpikaZYM plus is particularly beneficial for people with a protein-rich or gluten-containing diet, for gluten intolerances, to support an overburdened liver, during phases of increased metabolic stress, or for targeted digestive support. SpikaZYM plus is also a valuable supplement for ketogenic or vegan diets.
Yes! SpikaZYM plus is 100% vegan and suitable for a ketogenic diet. It contains no animal ingredients and is free from fillers, maltodextrin, stearates, and unnecessary additives.
Take 2 capsules daily with plenty of water – ideally 30 minutes before a meal. This allows the enzyme to optimally prepare to enter the small intestine and unfold its systemic effect there. Many people particularly like to take SpikaZYM plus before protein-rich or gluten-containing meals.
Yes, SpikaZYM plus can be well combined with other dr.reinwald vital products. It is particularly beneficial to combine it with Glutathion comp (for cell protection & detoxification), PektiCLEAN® (for the elimination of harmful substances), and VitaDK plus (for the immune system & metabolism). If you are taking blood-thinning medications at the same time, please consult your doctor beforehand.
A can contains 60 capsules and lasts for 30 days at the recommended daily dose of 2 capsules.
SpikaZYM plus combines three crucial advantages: (1) Proline specialist – while general proteases cover a broad spectrum, prolyl oligopeptidase specializes in breaking down hard-to-split proline peptides. (2) Substantial activity – 1,000,000 PPI per daily serving (many products: only 180,000 PPI). (3) Synergy approach – enzyme breaks down, milk thistle supports the liver in excretion. Enteric-coated capsules ensure optimal systemic release.