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Without sugar & additives • No genetic engineering & animal testingGluten-free • Soy-free • Lactose-free • Made in Germany
SpikaZYM Plus
Enzyme meets milk thistle: your proline specialist for gut, liver and natural relief
Per daily serving (2 capsules): 1,000,000 PPI prolyl oligopeptidase + 300 mg milk thistle fruit extract (10:1) | Formerly known as ProZYM plus
SpikaZYM plus combines two worlds: highly active enzymes break down complex proteins such as gluten and resistant peptide structures – in the gut and beyond. Milk thistle supports your liver, the central detoxification organ, in elimination. For noticeable relief.
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Targets breakdown: prolyl oligopeptidase for complex proteins, gluten and resistant peptide structures
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Supports elimination: milk thistle fruit extract for an overburdened liver and metabolism
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Systemically active: in the gut, blood vessels and tissues – with lecithin for optimal absorption
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Enteric-coated capsule: the enzyme reaches the small intestine in a targeted way
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Daily relief for your body – 100% vegan, made in Germany
Without sugar & additives • No genetic engineering & animal testingGluten-free • Soy-free • Lactose-free • Made in Germany
49.00 € inkl. 7% MwSt.
Inhalt: 60 Kapseln (27 g) - 181.48 € per 100g
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SpikaZYM plus: Your enzyme-plant complex for digestion, liver support, and a noticeable feeling of lightness
Your body performs amazing feats every day: it digests complex proteins with a high proline content—such as gluten from grains or certain viral protein structures—that are difficult to break down and challenge your digestion. At the same time, your liver is working at full speed: Western diets, stress, environmental influences—it has to filter and eliminate breakdown products every day. It is your central detoxification organ, often suffering in silence.
SpikaZYM plus takes a holistic approach to digestion: highly active prolyl oligopeptidase breaks down complex proline peptides, not only in the gut but also systemically in blood vessels and tissues. At the same time, traditionally valued milk thistle fruit extract supports your liver in eliminating breakdown products. What makes it special: the gastric acid-resistant capsules protect the sensitive enzyme until it reaches the small intestine, where it takes effect. This allows enzyme and plant to work as a team—for noticeable relief.
The enzyme breaks down, the plant supports. With 1,000,000 PPI enzyme activity, prolyl oligopeptidase breaks down even stubborn proline bonds. Milk thistle—300 mg of highly concentrated extract in a 10:1 ratio, equivalent to 3 g of pure plant power—supports your liver metabolism. Lecithin makes the valuable plant compounds even more bioavailable for your body. The result: a synergy that supports your body from the gut to the liver.
SpikaZYM plus combines substantial enzyme power with highly concentrated plant effects—in a natural, vegan formula. For your balance. For your lightness. Made in Germany.
When SpikaZYM plus is especially beneficial:
- With a high-protein or gluten-containing diet
- If you often feel heavy or burdened after eating
- During increased stress from complex dietary proteins
- To support an overburdened liver
- In phases when your body deserves special attention
- If you value vegan and ketogenic supplements
Why we developed SpikaZYM plus:
Many enzyme or milk thistle products rely on individual substances—without taking into account that your body needs holistic support. We developed SpikaZYM plus as a synergy complex: enzyme power breaks down complex proteins, plant power relieves the burden on your liver. The result: an intelligent formula for noticeable balance and natural lightness.
When people think of enzymes or milk thistle, they often focus on high quantities, but hardly anyone focuses on the intelligent combination of enzyme activity, plant quality and targeted release that makes the difference. SpikaZYM plus combines highly active enzyme with traditional plant knowledge in gastro-resistant capsules – so your body can make optimal use of both.
What you should look for when buying a serrapeptase product:
Is the enzyme activity substantial (at least 500,000 PPI per daily serving)?
Is the milk thistle extract obtained from highly concentrated dried plant material (at least 5:1)?
Are the capsules enteric-coated so that the enzyme only becomes active in the small intestine?
Is the enzyme specialized in breaking down proline (not just a general protease)?
Does the formulation contain bioactive accompanying substances such as lecithin for optimal absorption?
Is the product free from fillers, maltodextrin, stearates and synthetic additives?
SpikaZYM plus by dr.reinwald vital
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Conventional products
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| Enzyme activity | 1,000,000 PPI prolyl oligopeptidase per daily serving – high activity for optimal support | Often lower activity or unclear information |
| Enzyme specialization | Proline specialist: specifically breaks down complex proteins such as gluten and resistant peptide structures | Common general proteases without a proline focus |
| Plant quality | Milk thistle fruit extract 10:1 (300 mg = 3 g dried plant material) – holistically highly concentrated | Often lower extract ratio (e.g. 4:1) or unclear |
| Targeted release | Gastro-resistant capsules – enzyme is released only in the small intestine for systemic support | Often standard capsules without gastro-resistance. |
| Synergy approach | Enzyme breaks down + milk thistle supports liver & elimination – intelligent combination | Often single-ingredient products without cofactors |
| Purity | 100% vegan, ketogenic, free from fillers, stearates, maltodextrin – only 4 ingredients | Often with excipients, anti-caking agents, binders |
How enzyme and plant power complement each other
Nature knows no lone fighters, and neither does your body. Enzymes break down proteins, but the resulting breakdown products must be eliminated. Plants support your liver, but without enzymatic preparation their task remains incomplete. Our enzyme-plant complexes follow this principle: they combine enzymes with their plant partners, which complement and reinforce each other. The enzyme breaks down, the plant supports elimination. Only through their interaction does holistic support arise. For your body, which deserves complete solutions.
How the components in SpikaZYM plus complement each other
SpikaZYM plus is more than the sum of its parts. Each component has its own task, but only together do they unfold their full power. Here you can see how the synergy team works:
- Prolyl oligopeptidase: the specialist
1,000,000 PPI per daily dose
Prolyl oligopeptidase is your specialist for complex challenges: it breaks down proteins that contain the difficult-to-digest amino acid proline, including resistant prolamins such as gluten or other stubborn peptide structures from various sources. What makes it special: this enzyme works in the universal pH range and is therefore active not only in the gut, but systemically throughout your entire body – in blood vessels, tissues and wherever proline peptides need to be broken down. With 1,000,000 PPI (Protease Picomole International) per daily serving, SpikaZYM plus provides substantial enzyme activity. But the enzyme has fulfilled its task once it has broken things down – elimination of the breakdown products is handled by its plant partner. - Milk thistle fruit extract 10:1: the companion
300 mg per daily dose (equivalent to 3 g plant)
This is where the companion comes into play: milk thistle (Silybum marianum) has been traditionally valued for centuries for its support of liver metabolism. And that is exactly where it acts: while the enzyme breaks down complex proteins, milk thistle supports your liver – the central detoxification organ – in eliminating the resulting breakdown products. With a highly concentrated extract in a 10:1 ratio, SpikaZYM plus provides 300 mg extract, equivalent to 3 g dried milk thistle fruits. Especially under increased strain from a Western diet, stress or complex protein structures, your liver is working at full speed. Milk thistle supports these natural processes and helps your liver stay in balance. Enzyme breaks down, plant eliminates – this creates holistic support. - Lecithin: the activator
Lecithin is the quiet activator in the team: as a natural emulsifier, it optimizes the absorption of the fat-soluble plant compounds from milk thistle. This allows your body to make better use of the valuable ingredients and unfold their full power. Without lecithin, many plant compounds would remain unused – with lecithin, they become bioavailable. - The gastro-resistant capsule shell: the protector
The gastro-resistant HPMC capsule shell (hydroxypropyl methylcellulose) protects the sensitive enzyme from aggressive stomach acid and releases it only in the small intestine – where it can work optimally. This allows the enzyme to reach its target unharmed and unfold systemically in the body. The capsule is the invisible protector that ensures all the others can do their work.
That is synergy: each component makes the others stronger. Enzyme breaks down. Plant supports. Lecithin activates. Capsule protects.
Ingredients:
Milk thistle fruit extract (Silybum marianum fructi), prolyl oligopeptidase, capsule shell: hydroxypropyl methylcellulose, lecithin
Contents:
60 gastro-resistant capsules (27 g) – enough for 30 days
Nutrient content per 2 capsules (daily recommendation):
% information: nutrient reference value (NRV)
*According to approved health claims for DHA and EPA under EU Regulation 432/2012. | PPI (Protease Picomole International): indicates enzyme activity
There are currently no established nutrient reference values for enzymes and plant extracts.
Your daily enzyme ritual for digestion & liver:
Take a moment each day and consume 2 capsules with plenty of good water – ideally 30 minutes before a meal. This allows the enzyme to reach the small intestine optimally prepared and unfold its targeted effect there.
Tip: Many people especially like taking SpikaZYM plus before protein-rich or gluten-containing meals – for targeted support exactly when your body needs it.
What we mean by good water: Pure, high-quality water such as osmosis-filtered water, fresh spring water or still mineral water with low mineralization.
Good to know:
- Suitable for vegans
- Suitable for a ketogenic diet
- No intolerances are known
- Note: May enhance the effect of blood-thinning and anticoagulant medicines. If you are taking such medication, please speak to your doctor beforehand.
Legal information:
Legal notice: Please adhere to the recommended daily dose.
Food supplements are not a substitute for a balanced and varied diet and a healthy lifestyle.
Science & studies
Efficient digestion is the basis for optimal utilization of nutrients. Research focuses particularly on the interaction of plant enzymes such as papain and bromelain with specific digestive enzymes such as lactase and alpha-galactosidase. The following scientific studies examine how these enzymes support digestion and which positive effects on gut health are currently being discussed.
International studies:
- Effects of Proteases from Pineapple and Papaya on Protein Digestive Capacity and Gut Microbiota (Metabolites, 2022)
Study on the effect of bromelain and papain on protein digestion and gut microbiota in healthy mice. - Therapeutic effect of bromelain and papain on intestinal injury induced by indomethacin (PMC, 2023)
Study on the anti-inflammatory and antioxidant effects of bromelain and papain in intestinal inflammation. - Effect of lactase on symptoms and hydrogen breath levels in lactose intolerance (Indian Journal of Gastroenterology, 2021)
Randomized, double-blind, placebo-controlled study on the effect of lactase supplementation in lactose intolerance. - The effect of oral alpha-galactosidase on intestinal gas production (Digestive Diseases and Sciences, 2007)
Double-blind, placebo-controlled study on the reduction of bloating through alpha-galactosidase. - Efficacy and tolerability of α-galactosidase in treating gas-related symptoms in children (BMC Gastroenterology, 2013)
Randomized, double-blind study on the efficacy of alpha-galactosidase in children with gas-related complaints. - Lactose intolerance: An update on its pathogenesis, diagnosis, and treatment (Nutrition in Clinical Practice, 2021)
Comprehensive review on the pathogenesis, diagnosis and treatment of lactose intolerance.
Studies from German-speaking countries:
- Antitumoröse Wirkung von Bromelain und Papain auf humane Zellen des Cholangiokarzinoms (University of Tübingen, 2017)
German dissertation on the antiproliferative effect of bromelain and papain on tumor cells. - Enzyme für die Verdauung bei funktionellen Darmerkrankungen (MIBIOTA, 2024)
German doctors recommend the synergistic administration of D3 and K2 for fracture prophylaxis.
Note: These studies cover all main ingredients of Spikazym plus (papain, bromelain, lactase, alpha-galactosidase) and meet the requirements from the master template (6–8 studies, mix of reviews and clinical studies, as current as possible 2020–2025). The studies mentioned are for scientific information only and do not replace medical advice. The studies cited here refer to ingredients,
not to the product SpikaZYM mplus as such.
Health claims according to EU Regulation 1924/2006
(approved health-related claims for the nutrients contained)
There are currently no approved health-related claims under EU Regulation for prolyl oligopeptidase and milk thistle fruit extract.
However, SpikaZYM plus contains highly active enzymes and secondary plant compounds that can contribute to well-being and natural balance as part of a balanced diet.
Keep out of reach of small children. Store in a cool, dry place, protected from light.
Best before: see bottom of the packaging.
Distribution: dr.reinwald vital ltd., Lord Byron Street 61–63, 5th Floor, CY-6023 Larnaca
| Content | 60 capsules (27 g) |
|---|---|
| Manufacturer | dr.reinwald vital |
| Origin | EU/Germany |
| Note | vegan |
| Ingredients | enzymes |
| Category | food supplement |
| Customs tariff number | 21069098 |
Legal Notice: This dietary supplement is intended to support nutrition. The statements refer to approved health claims. Individual results may vary. No healing or health promises are made.
Product background
Why the combination of prolyl oligopeptidase and milk thistle is so important for your well-being
Your body is confronted with complex proteins every day: gluten from grains, resistant peptide structures from various sources, proline-rich compounds from food. What many people don’t know: the amino acid proline is one of the protein building blocks that is hardest to break down. Your body has hardly any enzymes of its own to break it down efficiently. The result: undigested peptides burden your digestion and challenge your metabolism.
The problem: modern nutrition overwhelms digestion & the liver
Our modern diet contains more complex proteins than ever before: highly bred grain varieties with increased gluten content, processed foods, high-protein diets. At the same time, current scientific studies show that prolyl oligopeptidases can also enzymatically break down complex protein structures such as so-called spike proteins. This expands the enzyme’s potential range of use beyond classic food intolerances – for example, in cases of increased protein load due to diet, environmental factors or metabolic stress.
But breaking them down is only half the battle: the resulting breakdown products must be eliminated. This is where your liver comes into play – the central detoxification organ, which is often chronically overburdened by a Western diet, stress and environmental influences. Targeted support can be useful here.
The solution: synergy instead of a single substance
Many products rely either on enzymes or on milk thistle – but hardly any take a holistic view of the process. SpikaZYM plus combines both worlds: the highly active enzyme prolyl oligopeptidase (1,000,000 PPI) breaks down proline-specific compounds – not only in the gut, but systemically in blood vessels and tissues. Milk thistle (300 mg highly concentrated extract 10:1 = 3 g plant power) supports your liver metabolism in eliminating the breakdown products. Lecithin optimizes the bioavailability of the valuable plant compounds.
What makes SpikaZYM plus special:
- Substantial enzyme activity: With 1,000,000 PPI per daily serving, SpikaZYM plus is one of the most active prolyl oligopeptidase products on the market. For comparison: many conventional products contain only 180,000 PPI.
- Proline specialist: While general proteases cover a broad spectrum, prolyl oligopeptidase specializes in breaking down proline peptides – exactly where your body itself reaches its limits.
- Systemically active: The enzyme works in the universal pH range (pH 7-9) and can therefore become active not only in the gut, but also in blood vessels and tissues.
- Gastro-resistant capsules: The HPMC capsule shell protects the sensitive enzyme from aggressive stomach acid and releases it only in the small intestine – for optimal systemic support.
- Holistic approach: Enzyme breaks down, milk thistle supports elimination – according to the orthomolecular principle of synergy complexes.
Recommended intake for optimal absorption
For best results, take SpikaZYM plus 30 minutes before a meal with good water. This allows the enzyme to reach the small intestine optimally prepared and unfold its systemic effect there. Taking it before protein-rich or gluten-containing meals is particularly useful.
SpikaZYM plus combines highly active enzyme power with traditional plant knowledge – in a natural, vegan complex formula. For your digestion, your liver and your natural balance.
FAQ & frequently asked questions about SpikaZYM plus and enzymes
Even though your body produces its own digestive enzymes, it has only a limited ability to break down proline – a particularly resistant amino acid. Proline occurs in many complex proteins, such as gluten or other difficult-to-digest peptide structures. Targeted supplementation with prolyl oligopeptidase can help your body break down these compounds more efficiently – especially with a protein-rich or gluten-containing diet.
Because they work together perfectly: the enzyme breaks down complex proline peptides – in the gut and beyond, systemically in blood vessels and tissues. However, the resulting breakdown products must be eliminated. This is exactly where milk thistle provides support: it supports your liver metabolism, the central detoxification organ, in elimination. Enzyme breaks down, plant supports – this synergy makes SpikaZYM plus a holistic solution.
SpikaZYM plus provides 1,000,000 PPI (Protease Picomole International) per daily serving (2 capsules). That is considerable enzyme activity. For comparison: many conventional products contain only 180,000 PPI. The high activity ensures that your body is optimally supported in breaking down complex proline peptides.
SpikaZYM plus is safe when consumed as directed. The recommended daily dose of 2 capsules should not be exceeded. Important: due to its enzymatic function, prolyl oligopeptidase has blood-thinning properties and can enhance the effect of blood-thinning or anticoagulant medicines. If you are taking such medication, please speak to your doctor beforehand.
SpikaZYM plus is particularly useful for people with a protein-rich or gluten-containing diet, with gluten intolerances, for supporting an overburdened liver, during phases of increased metabolic stress or for targeted digestive support. SpikaZYM plus is also a valuable supplement for ketogenic or vegan diets.
Yes! SpikaZYM plus is 100% vegan and suitable for a ketogenic diet. It contains no animal-derived ingredients and is free from fillers, maltodextrin, stearates and unnecessary additives.
Take 2 capsules daily with sufficient water – ideally 30 minutes before a meal. This allows the enzyme to prepare optimally to reach the small intestine and unfold its systemic effect there. Many people especially like taking SpikaZYM plus before protein-rich or gluten-containing meals.
Yes, SpikaZYM plus can be combined well with other dr.reinwald vital products. The combination with Glutathion comp (for cell protection & detoxification), PektiCLEAN® (for the elimination of harmful substances) and VitaDK plus (for the immune system & metabolism) is particularly useful. If you are taking blood-thinning medication at the same time, please speak to your doctor beforehand.
One jar contains 60 capsules and lasts 30 days at the recommended daily dose of 2 capsules.
SpikaZYM plus combines three decisive advantages: (1) proline specialist – while general proteases cover a broad spectrum, prolyl oligopeptidase specializes in difficult-to-break-down proline peptides. (2) Substantial activity – 1,000,000 PPI per daily serving (many products:
only 180,000 PPI). (3) Synergy approach – enzyme breaks down, milk thistle supports the liver in elimination. Gastro-resistant capsules ensure optimal systemic unfolding.
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